Department of Neurology, School of Medicine, University of Washington, Box 356465, 1959 NE Pacific Street, Seattle, WA 98195, USA.
J Neural Transm (Vienna). 2010 Aug;117(8):1001-8. doi: 10.1007/s00702-010-0430-7. Epub 2010 Jun 10.
Huntington's disease (HD) is a monogenic neurodegenerative disease characterized by abnormal motor movements, personality changes and early death. In contrast to other neurodegenerative diseases, very little is known about the role of neuroinflammation in HD. While the current data clearly demonstrate the existence of inflammatory processes in HD pathophysiology, the question of whether neuroinflammation is purely reactive or might actively participate in disease pathogenesis is currently a matter of ongoing research and debate. This review will try to shed some light on the current state of research in this area and provide an outlook on potential future developments.
亨廷顿病（HD）是一种单基因神经退行性疾病，其特征为异常运动、人格改变和早亡。与其他神经退行性疾病不同，人们对神经炎症在 HD 病理生理学中的作用知之甚少。虽然目前的数据清楚地表明了炎症过程在 HD 病理生理学中的存在，但神经炎症是纯粹的反应性的，还是可能主动参与疾病发病机制，目前仍是一个正在研究和争论的问题。本文综述试图阐明该领域的研究现状，并对潜在的未来发展提供展望。
