Vas'kova E A, Pavlova S V, Shevchenko A I, Zakinian S M
Genetika. 2010 Apr;46(4):437-47.
During meiosis, heteromorphic mammalian X and Y chromosomes in males undergo transcription silencing and form a compact structure, the XY body, containing specific modifications of the chromatin. In this review, we consider the dynamics of sex chromosome inactivation and discuss the suggestion that the paternally inherited X chromosome preserve inactivated state in zygote. This state results from meiotic silencing and is prone to imprinted inactivation, which his observed in mammalian females at early embryogenetic stages.
在减数分裂过程中，雄性哺乳动物中异型的X和Y染色体经历转录沉默并形成一种紧凑结构，即XY体，其中含有染色质的特定修饰。在这篇综述中，我们探讨了性染色体失活的动态变化，并讨论了父源遗传的X染色体在合子中保持失活状态的观点。这种状态源于减数分裂沉默，并且易于发生印记失活，这在哺乳动物雌性胚胎发育早期阶段可以观察到。
