Department of Dermatology, University Hospital, K.U.Leuven, B-3000 Leuven, Belgium.
Contact Dermatitis. 2010 May;62(5):303-8. doi: 10.1111/j.1600-0536.2010.01699.x.
Tetrazepam is a muscle relaxant belonging to the benzodiazepine group. Drug eruptions following ingestion of tetrazepam tablets are well known.
To draw the attention to occupational airborne dermatitis and/or hand dermatitis in nurses resulting from crushing of tablets for elderly or disabled people.
Since 2003, 16 nurses with facial (eyelid) and/or hand dermatitis, suspected to be of occupational origin, were patch tested with the medication they handled during work.
Ten nurses presented with a positive patch test reaction to tablets containing tetrazepam, 14 controls remaining negative. Some of them also reacted to other drugs.
Occupational airborne and/or hand contact dermatitis from tetrazepam might be much more common than suspected by dermatologists, particularly in view of the short period in which all cases have been observed.
替扎尼定是一种肌肉松弛剂，属于苯二氮䓬类药物。已知服用替扎尼定片会引起药物疹。
提请注意护士因给老年人或残疾人碾碎药片而导致职业性空气传播性皮炎和/或手部皮炎。
自 2003 年以来，16 名面部（眼睑）和/或手部患有皮炎的护士（疑似职业性起源）接受了他们在工作中处理的药物斑贴试验。
10 名护士对含有替扎尼定的片剂呈现阳性斑贴试验反应，14 名对照者仍为阴性。他们中的一些人也对其他药物有反应。
职业性空气传播和/或手部接触替扎尼定皮炎可能比皮肤科医生怀疑的更为常见，特别是考虑到所有病例观察到的时间很短。
