Stroke Unit, Department of Neurology, Royal Perth Hospital, Perth, Australia.
Int J Stroke. 2010 Jun;5(3):209-16. doi: 10.1111/j.1747-4949.2010.00429.x.
Stroke is a major cause of morbidity and mortality in Asia, and its pattern is changing. The incidence of haemorrhagic stroke is declining while the incidence of ischaemic stroke caused by large artery atherothromboembolism is increasing secondary to an increase in the prevalence of hypercholesterolaemia. The Working Group on Stroke and Lipids Management in Asia Consensus Panel assembled leading experts from the region to reach a consensus on how to address this challenge. The group discussed the observational epidemiology of the relationship between cholesterol and risk of stroke, the clinical trial evidence base for cholesterol-lowering for stroke prevention, and issues specific to stroke and lipid management for Asian doctors and patients. Stroke guidelines from many of the Asian countries have recently recommended consideration of statins for recurrent stroke prevention in patients with previous ischaemic stroke or transient ischaemic attack. However, because these recommendations have yet to be implemented widely, there is a need to educate Asian physicians and patients about the importance of adequate control of hypercholesterolaemia. Further trials of statins in Asian patients are also needed, particularly in those with intracranial stenosis.
中风是亚洲地区发病率和死亡率的主要原因，其模式正在发生变化。由于高胆固醇血症的患病率增加，导致由大动脉粥样硬化血栓栓塞引起的缺血性中风的发病率增加，出血性中风的发病率正在下降。亚洲卒中与血脂管理工作组共识专家组召集了该地区的主要专家，就如何应对这一挑战达成共识。该小组讨论了胆固醇与中风风险之间关系的观察性流行病学、胆固醇降低用于中风预防的临床试验证据基础，以及亚洲医生和患者在卒中与血脂管理方面的具体问题。最近，许多亚洲国家的中风指南建议考虑在既往缺血性中风或短暂性脑缺血发作患者中使用他汀类药物预防复发性中风。然而，由于这些建议尚未广泛实施，因此有必要教育亚洲医生和患者充分控制高胆固醇血症的重要性。还需要在亚洲患者中进行他汀类药物的进一步试验，特别是在颅内狭窄的患者中。
