Department of Psychiatry, Chonbuk National University Medical School & Institute for Medical Sciences, Jeonju, Korea.
Early Interv Psychiatry. 2010 May;4(2):124-31. doi: 10.1111/j.1751-7893.2010.00170.x.
Previous studies have shown that the individuals at high risk for psychosis suffer from depression, anxiety, and deficits in social functioning. The present report describes help-seeking behaviours, baseline psychopathology, and duration of attenuated psychotic symptoms (DUAPS) and their associations with other variables.
Using the Comprehensive Assessment of At-Risk Mental States (CAARMS), we conducted systematic evaluations of individuals at high risk for psychosis. Help-seeking behaviours, current Axis I diagnoses, DUAPS, and baseline psychopathology were investigated. Demographic and clinical characteristics of short and long DUAPS groups were compared.
Thirty-eight subjects were recruited from nine centres. Participants seldom sought psychiatric services at their first help-seeking contact, and the mean DUAPS was 22.00 +/- 28.59 months. Most participants had current Axis I diagnoses, and depressive disorder NOS was the most common of these. Higher levels of depression, anxiety, obsessive-compulsive symptoms, and functional impairment were also identified. We found no significant differences between short and long DUAPS groups in baseline psychopathology. However, we observed significantly lesser distressing intensity of thought contents and significantly greater social impairment in the long-DUAPS group.
These findings suggest that high-risk subjects frequently received delayed treatment despite symptomatic distress and functional impairment. No direct evidence supporting the delayed effect of the DUAPS on baseline psychopathology was found.
先前的研究表明，处于精神病高危状态的个体患有抑郁、焦虑和社交功能障碍。本报告描述了寻求帮助的行为、基线精神病学特征以及前驱期精神病症状（DUAPS）的持续时间及其与其他变量的关系。
我们使用精神病高危人群综合评估量表（CAARMS）对处于精神病高危状态的个体进行了系统评估。我们调查了寻求帮助的行为、当前轴 I 诊断、DUAPS 和基线精神病学特征。比较了 DUAPS 长短组的人口统计学和临床特征。
从九个中心招募了 38 名受试者。参与者在首次寻求帮助时很少寻求精神科服务，平均 DUAPS 为 22.00 +/- 28.59 个月。大多数参与者有当前的轴 I 诊断，其中最常见的是未特定的抑郁障碍。还发现了更高水平的抑郁、焦虑、强迫症状和功能障碍。我们在基线精神病学特征方面未发现 DUAPS 长短组之间有显著差异。然而，我们观察到长 DUAPS 组的思维内容困扰强度显著较小，社会功能障碍显著较大。
这些发现表明，尽管有症状困扰和功能障碍，高风险个体仍经常接受延迟治疗。没有直接证据支持 DUAPS 对基线精神病学特征的延迟影响。
