Hidiroglou M, Charmley E
Animal Research Centre, Ottawa, Ontario, Canada.
Am J Vet Res. 1991 Apr;52(4):640-2.
An experiment was conducted to compare the bioavailability of dl-alpha-tocopherol acetate (TA) with that of dl-alpha-tocopherol nicotinate (TN) when administered to sheep, as a single dose, either into the rumen or the peritoneal cavity. A total of 16 sheep were used in a factorial design, with 4 sheep/treatment at the interaction level. In addition, 5 sheep that received no supplemental alpha-tocopherol, were euthanatized at the end of the trial to provide base-line data for tissue alpha-tocopherol concentrations. Curves were fitted to the plasma alpha-tocopherol concentration values, taken over 180 hours after administration of the esters. Availability of TA was greater than TN, as evidenced by the significantly higher curve parameter values (P less than 0.05) and tissue concentrations (P less than 0.05). Route of administration had a marked effect on availability of TA (P less than 0.001), but not of TN.
进行了一项实验，以比较将dl-α-生育酚醋酸酯（TA）和dl-α-生育酚烟酸酯（TN）单剂量经瘤胃或腹腔注射给绵羊后的生物利用度。总共16只绵羊采用析因设计，在交互水平上每个处理有4只绵羊。此外，5只未补充α-生育酚的绵羊在试验结束时实施安乐死，以提供组织α-生育酚浓度的基线数据。对酯类给药后180小时内采集的血浆α-生育酚浓度值进行曲线拟合。TA的生物利用度高于TN，曲线参数值（P<0.05）和组织浓度（P<0.05）显著更高证明了这一点。给药途径对TA的生物利用度有显著影响（P<0.001），但对TN没有影响。
