Nijmegen Centre for Molecular Life Sciences, Department of Tumor Immunology, Nijmegen, The Netherlands.
J Neuroimmunol. 2010 Aug 25;225(1-2):195-9. doi: 10.1016/j.jneuroim.2010.05.020.
Regulatory T cells (Tregs) accumulate in tumors and can contribute to the dismal immune responses observed in these tumors. We reported that the percentage of tumor infiltrating Tregs is strongly correlated with the WHO grade of the brain tumor. We now report on the clinical follow-up of this patient cohort (n=83). Subgroup analyses in patients with glioblastomas (n=29) showed a moderate, not significant, inverted association between Tregs and survival. We further show that Tregs in glioblastomas, in contrast to other tumor infiltrating effector lymphocytes, highly express the CCR4 chemokine receptor. Moreover, the CCR4 ligand CCL22 is secreted by glioblastomas and may explain the specific Treg accumulation seen in these tumors.
调节性 T 细胞（Tregs）在肿瘤中积累，并可能导致这些肿瘤中观察到的免疫反应不佳。我们报告称，肿瘤浸润性 Tregs 的百分比与脑肿瘤的世界卫生组织分级强烈相关。我们现在报告该患者队列的临床随访结果（n=83）。在胶质母细胞瘤患者（n=29）的亚组分析中，Tregs 与生存之间存在中度但无统计学意义的倒置关联。我们进一步表明，与其他肿瘤浸润效应淋巴细胞相比，胶质母细胞瘤中的 Tregs 高度表达 CCR4 趋化因子受体。此外，胶质母细胞瘤分泌 CCR4 配体 CCL22，这可能解释了这些肿瘤中特异性 Treg 积累的原因。
