Research Center, Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada.
Cardiovasc Pathol. 2011 May-Jun;20(3):e85-9. doi: 10.1016/j.carpath.2010.04.005. Epub 2010 Jun 7.
Early prediction of infarct size and of the subsequent development of congestive heart failure (CHF) and pulmonary hypertension (PH) would be useful in therapeutic trials using the rat myocardial infarction (MI) model.
A total of 194 rats were subjected to MI or sham surgery, and plasma cardiac troponin T (cTnT) was measured 24 h after surgery in rats. Echocardiography was performed after 2 and 5 weeks. Hemodynamic and morphometric parameters were evaluated 5 weeks after MI.
cTnT had strong positive correlations with left ventricular (LV) wall motion abnormalities at 2 and 5 weeks (R=.85 and .89; P<.0001), and with histological infarct size (R=.87, P<.0001). cTnT ≥5.1 μg/l predicted LV wall motion abnormalities ≥ 30% with a sensitivity of 90.9% and specificity of 84.0%. Rats with cTnT≥5.1 μg/l developed PH [right ventricular (RV) systolic pressure 37 ± 3 vs. 23 ± 0.6 mmHg], RV hypertrophy (RV/LV+septum weight 42 ± 4% vs. 24 ± 0.5%), and lung structural remodeling (all P<.01).
Early single cTnT measurement correlates with infarct size in rats, and a cutoff value of 5.1 μg/l provides good sensitivity and specificity to predict CHF with secondary PH. cTnT could be used for treatment allocations in therapeutic trials of secondary pulmonary hypertension using this model.
在使用大鼠心肌梗死（MI）模型的治疗试验中，早期预测梗死面积以及随后充血性心力衰竭（CHF）和肺动脉高压（PH）的发展将是有用的。
共有 194 只大鼠接受 MI 或假手术，手术后 24 小时测量血浆心肌肌钙蛋白 T（cTnT）。手术后 2 周和 5 周进行超声心动图检查。MI 后 5 周评估血流动力学和形态计量学参数。
cTnT 与 2 周和 5 周时的左心室（LV）壁运动异常呈强正相关（R=.85 和.89；P<.0001），与组织学梗死面积呈强正相关（R=.87，P<.0001）。cTnT≥5.1μg/l 预测 LV 壁运动异常≥30%，具有 90.9%的敏感性和 84.0%的特异性。cTnT≥5.1μg/l 的大鼠发生 PH[右心室（RV）收缩压 37±3 与 23±0.6mmHg]、RV 肥厚（RV/LV+室间隔重量 42±4%与 24±0.5%）和肺结构重塑（均 P<.01）。
早期单次 cTnT 测量与大鼠梗死面积相关，5.1μg/l 的截断值可提供良好的敏感性和特异性，以预测继发 PH 的 CHF。cTnT 可用于该模型中继发肺动脉高压治疗试验的治疗分配。
