Department of Pathology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
J Clin Neurosci. 2010 Oct;17(10):1271-5. doi: 10.1016/j.jocn.2009.12.014. Epub 2010 May 26.
Rhabdoid meningioma is an uncommon variant of meningioma, and was classified separately for the first time in the 2000 World Health Organization's classification of tumors of the nervous system. Because it often shows malignant histological features and follows an aggressive clinical course, it has been classified as a grade III neoplasm. We describe the clinicopathologic features of 13 patients with this rare tumor. From 13 patients (seven male, six female), 19 specimens of rhabdoid meningioma were obtained between 2001 and 2009. The mean age of patients was 50.4years at their first operation. The mean postoperative follow-up period was 35.7months. Five patients experienced tumor recurrence, and two patients died from the disease. The mean time to first recurrence was 36.1months. The recurrence-free survival rates at 1 and 5years were 62% and 23%, respectively. Immunohistochemically, all tumors were positive for vimentin and epithelial membrane antigen. MIB-1 labeling indices were higher following tumor recurrence. Close follow-up and aggressive treatment of these tumors is warranted.
横纹肌样脑膜瘤是脑膜瘤的一种罕见亚型，在 2000 年世界卫生组织神经系统肿瘤分类中首次被单独分类。由于它常表现出恶性组织学特征和侵袭性临床病程，因此被归类为 3 级肿瘤。我们描述了 13 例这种罕见肿瘤患者的临床病理特征。13 例患者（男 7 例，女 6 例）在 2001 年至 2009 年间共获得 19 例横纹肌样脑膜瘤标本。患者的平均年龄为首次手术时 50.4 岁。平均术后随访时间为 35.7 个月。5 例患者发生肿瘤复发，2 例患者死于该疾病。首次复发的平均时间为 36.1 个月。1 年和 5 年无复发生存率分别为 62%和 23%。免疫组化染色均显示波形蛋白和上皮膜抗原阳性。肿瘤复发后 MIB-1 标记指数更高。需要对这些肿瘤进行密切随访和积极治疗。
