Federal University of Rio Grande do SulPorto Alegre, Brazil.
Arch Oral Biol. 2010 Jul;55(7):523-9. doi: 10.1016/j.archoralbio.2010.05.003. Epub 2010 Jun 9.
A recent consensus report could not find specific reports of the effect of nifedipine on the destruction of the periodontal tissues. The aim of the present study was to evaluate the effect of nifedipine on gingival enlargement and periodontal breakdown using a ligature-induced periodontitis in rats.
Fifty, male, 60 days old, Wistar rats, were divided into six groups. Cotton sutures were placed around the upper second molars. Two groups of 10 rats each did not receive ligatures and were treated daily with either saline solution or nifedipine 50mg/kg/day. Two groups of 10 rats received ligatures and were also treated daily with saline solution or nifedipine 50mg/kg/day. Two additional groups (nifedipine 10 and 100mg/kg/day) were included to explore a possible dose-response relationship. Animals were euthanatised at 30 days. Internal and oral epithelium, total and inflamed connective tissue, gingival thickness and height, and bone loss were assessed histologically.
Nifedipine alone was not sufficient to promote gingival enlargement or periodontal destruction in the absence of the ligature. Compared to animals with ligatures only, the group that received ligatures and nifedipine 50mg/kg/day showed significant higher estimates for total and inflamed connective tissue, gingival thickness and height. No significant differences were observed for bone loss between these experimental groups. The other dosages of nifedipine did not provide additional information.
Nifedipine itself did not lead to gingival enlargement in rats. In the presence of biofilm accumulation, nifedipine yielded greater gingival enlargement and periodontal inflammation, but it did not increase periodontal destruction.
最近的一份共识报告未能找到硝苯地平对牙周组织破坏影响的具体报告。本研究旨在通过结扎诱导的大鼠牙周炎评估硝苯地平对牙龈增大和牙周破坏的影响。
50 只 60 天大的雄性 Wistar 大鼠被分为六组。棉线结扎在上颌第二磨牙周围。两组各 10 只大鼠不结扎，每天用生理盐水或硝苯地平 50mg/kg/天处理。两组各 10 只大鼠结扎，每天用生理盐水或硝苯地平 50mg/kg/天处理。还纳入了两组（硝苯地平 10 和 100mg/kg/天）以探索可能的剂量反应关系。动物在 30 天处死。组织学评估上皮内和口腔上皮、总结缔组织和炎症性结缔组织、牙龈厚度和高度以及骨损失。
单独使用硝苯地平在没有结扎的情况下不足以促进牙龈增大或牙周破坏。与仅结扎的动物相比，接受结扎和硝苯地平 50mg/kg/天治疗的组显示出总结缔组织和炎症性结缔组织、牙龈厚度和高度的显著更高估计值。这些实验组之间的骨损失没有观察到显著差异。其他硝苯地平剂量没有提供额外的信息。
硝苯地平本身不会导致大鼠牙龈增大。在生物膜积聚的情况下，硝苯地平导致更大的牙龈增大和牙周炎症，但不会增加牙周破坏。
