Boulanger C, Vanhoutte P M
Département de recherche, hôpital universitaire, Bâle, Suisse.
Arch Mal Coeur Vaiss. 1991 Jan;84 Spec No 1:35-44.
The classical physiological concept of the endothelium was that of a barrier and a surface of exchange. Little importance was attached to its role in the regulation of vascular tone. Successively, prostacycline, the endothelium-derived relaxing factor, the hyperpolarizing factor, the endothelium-derived contracting factor and especially endothelin, were discovered and their physiological effects are currently under evaluation. These different factors and their possible roles in vascular pathology are reviewed. The endothelial function or functions are probably abnormal in many pathological situations.
内皮的经典生理学概念是作为屏障和交换表面。人们对其在血管张力调节中的作用重视不足。随后，前列环素、内皮源性舒张因子、超极化因子、内皮源性收缩因子，尤其是内皮素被发现，它们的生理作用目前正在评估中。本文综述了这些不同的因子及其在血管病理学中可能发挥的作用。在许多病理情况下，内皮功能可能是异常的。
