Maghzi Amir-Hadi, Marta Monica, Bosca Isabel, Etemadifar Masoud, Dobson Ruth, Maggiore Cosimo, Giovannoni Gavin, Meier Ute-Christiane
Neuroimmunology Unit, Centre for Neuroscience & Trauma, Blizard Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, London, UK; Isfahan Research Committee of Multiple Sclerosis (IRCOMS), Isfahan, Iran; Isfahan Neuroscience Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Pathophysiology. 2011 Feb;18(1):13-20. doi: 10.1016/j.pathophys.2010.04.003. Epub 2010 Jun 9.
Multiple sclerosis (MS) is the most common inflammatory demyelinating and degenerative disease of the CNS. The cause of MS is unknown but environmental risk factors are implicated in MS. Several viruses have been proposed as a trigger for MS, and lately Epstein-Barr virus (EBV) has become the leading candidate. An infectious aetiology fits with a number of epidemiological observations in addition to the immunopathological features of the disease. In this review we will summarize the emerging evidence, which demonstrates a strong association between EBV infection and MS. The conundrum remains as to whether EBV is directly involved in the pathophysiology of MS, or alternatively if the immunopathology of MS somehow affects the regulation of EBV infection.
多发性硬化症（MS）是中枢神经系统最常见的炎性脱髓鞘和退行性疾病。MS的病因尚不清楚，但环境危险因素与MS有关。几种病毒已被提出作为MS的触发因素，最近爱泼斯坦-巴尔病毒（EBV）已成为主要候选因素。除了该疾病的免疫病理特征外，感染性病因还符合一些流行病学观察结果。在本综述中，我们将总结新出现的证据，这些证据表明EBV感染与MS之间存在密切关联。关于EBV是否直接参与MS的病理生理学，或者MS的免疫病理学是否以某种方式影响EBV感染的调节，这一难题仍然存在。
