Cambridge Centre for Medical Materials, Department of Materials Science and Metallurgy, University of Cambridge, Cambridge, UK.
J R Soc Interface. 2010 Oct 6;7 Suppl 5(Suppl 5):S663-74. doi: 10.1098/rsif.2010.0014.focus. Epub 2010 Jun 10.
This study investigates the in vitro degradation properties of composites consisting of a porous tricalcium phosphate (TCP) foam filled with degradable poly(dl-lactic acid) (PDLLA) via either in situ polymerization or infiltration. The motivation was to develop a material for bone repair that would be initially mechanically strong and would develop porosity during degradation of one of the components. A thorough analysis of the physical in vitro degradation properties has been conducted and reported by the same authors elsewhere. Synchrotron micro-computer tomography analysis (conducted at ID19, ESRF, Grenoble, France) allowed detailed insights to be gained into the process of the composites' degradation, which was discovered to be strongly influenced by the manufacturing method. The polymer phase of in situ-polymerized TCP-PDLLA degraded as a bulk sample, with faster degradation in the centre of the sample as a whole. In contrast, the polymer phase of infiltrated TCP-PDLLA degraded as individual polymer spheres with faster degradation in the centre of each sphere.
本研究通过原位聚合或渗透的方式，研究了由多孔磷酸三钙 (TCP) 泡沫填充可降解聚（DL-乳酸）（PDLLA）组成的复合材料的体外降解性能。其动机是开发一种用于骨修复的材料，该材料最初具有较强的机械强度，并在其中一种成分降解过程中会产生多孔性。作者在别处对物理体外降解性能进行了全面分析。同步加速器微计算机断层扫描分析（在法国格勒诺布尔的 ESRF 的 ID19 进行）使我们能够详细了解复合材料降解的过程，发现该过程受制造方法的强烈影响。原位聚合 TCP-PDLLA 的聚合物相作为整体块状样品进行降解，整体中心的降解速度更快。相比之下，渗透 TCP-PDLLA 的聚合物相作为单个聚合物球进行降解，每个球的中心降解速度更快。
