Institut National de la Santé et de la Recherche Médicale (INSERM) U892, IRT UN, 8 quai Moncousu, BP 70721, 44007 Nantes cedex 1, France.
Nat Rev Immunol. 2010 Jul;10(7):467-78. doi: 10.1038/nri2781. Epub 2010 Jun 11.
Gammadelta T cells have several innate cell-like features that allow their early activation following recognition of conserved stress-induced ligands. Here we review recent observations revealing the ability of gammadelta T cells to rapidly produce cytokines that regulate pathogen clearance, inflammation and tissue homeostasis in response to tissue stress. These studies provide insights into how they acquire these properties, through both developmental programming in the thymus and functional polarization in the periphery. Innate features of gammadelta T cells underlie their non-redundant role in several physiopathological contexts and are therefore being exploited in the design of new immunotherapeutic approaches.
γδ T 细胞具有多种先天的类似细胞的特征，使其在识别保守的应激诱导配体后能够早期激活。在这里，我们回顾了最近的观察结果，这些结果揭示了 γδ T 细胞能够迅速产生细胞因子的能力，这些细胞因子调节病原体清除、炎症和组织稳态反应，以应对组织应激。这些研究提供了关于它们如何通过在胸腺中的发育编程和在外周中的功能极化来获得这些特性的深入了解。γδ T 细胞的先天特征是它们在几种生理病理情况下发挥非冗余作用的基础，因此正在被用于设计新的免疫治疗方法。
