Department of Inorganic Chemistry, Wrocław Medical University, Szewska 38, 50-139, Wrocław, Poland.
Dalton Trans. 2010 Jul 28;39(28):6518-23. doi: 10.1039/b923371g. Epub 2010 Jun 11.
The coordination abilities of tetrapeptides containing beta-amino acids towards Cu(II) ions are presented. The studied tetrapeptides were: Ac-betaAlaHisGlyHis, betaAlaHisGlyHis, Ac-betaAspHisGlyHis, betaAspHisGlyHis, Ac-betaAspHisGly-dHis and betaAspHisGly-dHis. Thorough potentiometric titrations were carried out to establish the stoichiometry of the resulting metal-ligand complexes and the role of free -alphaCOO(-) side chain group in metal binding. The copper(II) coordination mode of the complexes was investigated by performing detailed spectroscopic analyses (UV-Vis, EPR, CD) in strict correlation with potentiometric measurements.
呈现了含有β-氨基酸的四肽与 Cu(II) 离子的配位能力。研究的四肽为：Ac-βAlaHisGlyHis、βAlaHisGlyHis、Ac-βAspHisGlyHis、βAspHisGlyHis、Ac-βAspHisGly-dHis 和 βAspHisGly-dHis。通过详细的电位滴定实验确定了生成的金属-配体配合物的化学计量比，并研究了游离 -αCOO（-）侧链基团在金属结合中的作用。通过与电位测量严格相关的详细光谱分析（UV-Vis、EPR、CD）研究了配合物的铜（II）配位模式。
