Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, USA.
J Org Chem. 2010 Jul 16;75(14):4657-73. doi: 10.1021/jo1006812.
The field of total synthesis has a rich history and a vibrant future. Landmark advances and revolutionary strides in the logic of synthesis have put the practicing chemist in the enviable position of being able to create nearly any molecule with enough time and effort. The stage is now set for organic chemists to aim for "ideality" in the way molecules are synthesized. This perspective presents a simple and informative definition of "ideality" and demonstrates its use during the self-evaluation of several syntheses from our laboratory.
全合成领域有着丰富的历史和充满活力的未来。在合成逻辑方面的里程碑式进展和革命性突破，使实践化学家能够在有足够的时间和精力的情况下创造几乎任何分子。现在，有机化学家的目标是在合成分子的方式上追求“理想”。本文提出了“理想”的一个简单而有信息量的定义，并展示了在我们实验室的几个合成的自我评价中使用该定义的情况。
