18F-脱氧葡萄糖（FDG）摄取的 PET 与非小细胞肺癌中葡萄糖转运蛋白基因（SLC2A1）和缺氧相关基因（HIF1A、VEGFA、APEX1）的多态性的相关性。SLC2A1 多态性与非小细胞肺癌患者的 FDG-PET。
The association of 18F-deoxyglucose (FDG) uptake of PET with polymorphisms in the glucose transporter gene (SLC2A1) and hypoxia-related genes (HIF1A, VEGFA, APEX1) in non-small cell lung cancer. SLC2A1 polymorphisms and FDG-PET in NSCLC patients.
机构信息
Departments of Laboratory Medicine, Pusan National University Hospital, School of Medicine Pusan National University, Busan, Korea.
出版信息
J Exp Clin Cancer Res. 2010 Jun 12;29(1):69. doi: 10.1186/1756-9966-29-69.
BACKGROUND
Positron emission tomography imaging of lung cancers with 2-[fluorine-18]-fluoro-2-deoxy-D-glucose is a non-invasive diagnostic, and prognostic tool that measures tumor metabolism. We have analyzed the effect of solute carrier family 2 (facilitated glucose transporter), member 1 polymorphisms on 2-[fluorine-18]-fluoro-2-deoxy-D-glucose-uptake with a combination of polymorphisms of hypoxia-inducible factor 1 alpha, apurinic/apyimidinic endonuclease, and vascular endothelial growth factor A in a hypoxia-related pathway.
METHODS
We investigated the association between solute carrier family 2 (facilitated glucose transporter), member 1 -2841A>T, hypoxia-inducible factor 1 alpha Pro582Ser, Ala588Thr, apurinic/apyimidinic endonuclease Asp148Glu, or vascular endothelial growth factor A +936C>T and 2-[fluorine-18]-fluoro-2-deoxy-D-glucose-uptake among 154 patients with non-small-cell lung cancer.
RESULTS
The solute carrier family 2 (facilitated glucose transporter), member 1 -2841A>T polymorphism was significantly associated with 2-[fluorine-18]-fluoro-2-deoxy-D-glucose-uptake in combination with the apurinic/apyimidinic endonuclease Asp148Glu (T>G) polymorphism in the squamous cell type of non-small-cell lung cancer. The solute carrier family 2 (facilitated glucose transporter), member 1 TT genotype had a higher maximum standardized uptake values than the AA + AT genotype when the apurinic/apyimidinic endonuclease genotype was TT (mean maximum standardized uptake values, 12.47 +/- 1.33 versus 8.46 +/- 2.90, respectively; P = 0.028). The mean maximum standardized uptake values were not statistically different with respect to vascular endothelial growth factor A and hypoxia-inducible factor 1 alpha polymorphisms.
CONCLUSION
A glucose transporter gene polymorphism was shown to be statistically associated with glucose-uptake when the apurinic/apyimidinic endonuclease genotype is TT in patients with the squamous cell type of non-small-cell lung cancer. Our findings suggest that a newly developed tracer for positron emission tomography could be affected by genetic polymorphisms.
背景
正电子发射断层扫描成像的肺癌与 2 - [氟- 18] - 氟- 2 - 脱氧-D -葡萄糖是一种非侵入性的诊断，以及预后工具，测量肿瘤代谢。我们已经分析了溶质载体家族 2（促进葡萄糖转运体），成员 1 多态性对 2 - [氟- 18] - 氟- 2 - 脱氧-D -葡萄糖摄取与缺氧诱导因子 1 ɑ，apurinic/apyimidinic 内切酶，和血管内皮生长因子 A 在缺氧相关途径的组合。
方法
我们调查了溶质载体家族 2（促进葡萄糖转运体），成员 1 -2841A>T，缺氧诱导因子 1 ɑ Pro582Ser，Ala588Thr，apurinic/apyimidinic 内切酶 Asp148Glu，或血管内皮生长因子 A +936C>T 和 2 - [氟- 18] - 氟- 2 - 脱氧-D -葡萄糖摄取之间的 154 例非小细胞肺癌患者。
结果
溶质载体家族 2（促进葡萄糖转运体），成员 1 -2841A>T 多态性与 2 - [氟- 18] - 氟- 2 - 脱氧-D -葡萄糖摄取显著相关与 apurinic/apyimidinic 内切酶 Asp148Glu （T>G）多态性在非小细胞肺癌的鳞状细胞类型。溶质载体家族 2（促进葡萄糖转运体），成员 1 TT 基因型有更高的最大标准化摄取值比 AA + AT 基因型当 apurinic/apyimidinic 内切酶基因型是 TT （平均最大标准化摄取值，12.47 +/- 1.33 与 8.46 +/- 2.90，分别; P = 0.028）。血管内皮生长因子 A 和缺氧诱导因子 1 ɑ 多态性与最大标准化摄取值无统计学差异。
结论
葡萄糖转运体基因多态性与葡萄糖摄取有关，当 apurinic/apyimidinic 内切酶基因型是 TT 时，非小细胞肺癌的鳞状细胞类型的患者。我们的研究结果表明，新开发的正电子发射断层扫描示踪剂可能受到遗传多态性的影响。
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