Taipei Medical University, Taiwan.
Can J Psychiatry. 2010 Jun;55(6):377-85. doi: 10.1177/070674371005500607.
Paternal characteristics have never been considered in the relation between maternal schizophrenia and adverse pregnancy outcomes. The aim of our study was to consider different paternal ages while investigating the relation between maternal schizophrenia and low birth weight (LBW), using a nationwide population-based dataset.
Our study used data from the 2001 to 2003 Taiwan National Health Insurance Research Dataset and birth certificate registry. A total of 543 394 singleton live births were included. We performed multivariate logistic regression analyses to explore the relation between maternal schizophrenia and the risk of LBW, taking different paternal age groups into account (aged 29 years or younger, 30 to 39 years, and 40 years and older), and after adjusting for other characteristics of infant, mother, and father as well as the difference between the parent's ages.
Mothers with schizophrenia had a higher percentage of LBW infants than mothers who did not (11.8%, compared with 6.8%). For infants whose mothers had schizophrenia, the adjusted odds ratios of LBW were 1.47 (95% CI 1.02 to 2.27, P < 0.05) and 2.80 (95% CI 1.42 to 5.51, P < 0.01) times greater than for infants whose mothers did not have schizophrenia, for paternal age groups of 30 to 39 years and 40 years or older, respectively. However, maternal schizophrenia was not a significant predictor of LBW for infants whose fathers were aged 29 years and younger.
The relation between LBW and maternal schizophrenia is modified by paternal age. More attention should be paid to the interaction of paternal characteristics and maternal psychiatric disorders in producing adverse pregnancy outcomes.
母亲精神分裂症与不良妊娠结局之间的关系从未考虑过父亲的特征。我们的研究目的是在考虑不同的父亲年龄的情况下，研究母亲精神分裂症与低出生体重（LBW）之间的关系，使用全国性的基于人群的数据集。
我们的研究使用了 2001 年至 2003 年台湾全民健康保险研究数据集和出生证明登记处的数据。共纳入 543394 例单胎活产。我们进行了多变量逻辑回归分析，以探讨母亲精神分裂症与 LBW 风险之间的关系，同时考虑了不同的父亲年龄组（29 岁或以下、30 岁至 39 岁和 40 岁及以上），并在调整了婴儿、母亲和父亲的其他特征以及父母年龄差异后进行了分析。
患有精神分裂症的母亲所生的 LBW 婴儿比例高于未患精神分裂症的母亲（11.8%，对比 6.8%）。对于母亲患有精神分裂症的婴儿，LBW 的调整比值比分别为 1.47（95%可信区间 1.02 至 2.27，P < 0.05）和 2.80（95%可信区间 1.42 至 5.51，P < 0.01），这两个比值比分别大于母亲未患精神分裂症的婴儿。对于父亲年龄在 30 岁至 39 岁和 40 岁及以上的婴儿，分别为 1.47（95%可信区间 1.02 至 2.27，P < 0.05）和 2.80（95%可信区间 1.42 至 5.51，P < 0.01）。然而，对于父亲年龄在 29 岁及以下的婴儿，母亲精神分裂症并不是 LBW 的显著预测因素。
LBW 与母亲精神分裂症之间的关系受到父亲年龄的影响。在产生不良妊娠结局方面，应更加关注父亲特征与母亲精神疾病之间的相互作用。
