不同压力大小对中国人群肥厚性瘢痕的影响。

Effect of different pressure magnitudes on hypertrophic scar in a Chinese population.

机构信息

Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.

出版信息

Burns. 2010 Dec;36(8):1234-41. doi: 10.1016/j.burns.2010.05.008. Epub 2010 Jun 11.

DOI:10.1016/j.burns.2010.05.008

PMID:20541324

Abstract

INTRODUCTION

This study aimed to investigate the effect of different pressure magnitudes on treatment outcomes of hypertrophic scars, and determine pressure loss over time.

METHODS

A randomized clinical trial was adopted. 53 hypertrophic scar samples from 17 Chinese participants were recruited and randomly assigned into a high pressure group (20-25 mmHg) and low pressure group (10-15 mmHg) for a five-month intervention program. The scars were assessed objectively before intervention and monthly after intervention for thickness, color (redness, yellowness and lightness) and scar pliability. Pressure magnitude at each assessment was also measured. Two-way repeated ANOVA was used to compare for differences between groups.

RESULTS

The results showed that both levels of pressure produced reduction in scar thickness and redness, but the improvement in the high pressure group was statistically better than that of the counterpart (both p<0.05). Monthly pressure measurement revealed that pressure loss in the high pressure group was more severe. However, no major changes in other color parameters and pliability were observed for both the groups.

CONCLUSION

High pressure was demonstrated to be more effective for scar management, but it was also more prone to higher pressure loss. Pressure therapy integrated with regular monitoring of the interface pressure is suggested to improve its therapeutic efficacy.

摘要

简介

本研究旨在探讨不同压力大小对增生性瘢痕治疗效果的影响，并确定压力随时间的损失。

方法

采用随机临床试验。从 17 名中国参与者中招募了 53 个增生性瘢痕样本，并将其随机分为高压组（20-25mmHg）和低压组（10-15mmHg）进行为期五个月的干预计划。在干预前和干预后每月对瘢痕进行客观评估，评估指标包括厚度、颜色（红色、黄色和亮度）和瘢痕柔韧性。每次评估时还测量压力大小。采用双因素重复方差分析比较组间差异。