角叉菜胶诱导的急性爪部炎症期间大鼠脑内源性单胺氧化酶抑制剂（三溴藜芦碱）的活性

Rat brain endogenous MAO inhibitor (tribulin) activity during carrageenan-induced acute paw inflammation.

作者信息

Bhattacharya S K, Tripathi M, Acharya S B

机构信息

Department of Pharmacology, Banaras Hindu University, Varanasi, India.

出版信息

J Neural Transm Gen Sect. 1991;84(1-2):135-40. doi: 10.1007/BF01249117.

DOI:10.1007/BF01249117

PMID:2054145

Abstract

The endogenous monoamine oxidase (MAO) inhibitor (tribulin) activity of rat brain was investigated during the course of carrageenan induced acute paw inflammation. The increase in rat brain tribulin activity closely paralleled the time course intensity of the inflammation. The study indicates that, like externally induced stress, internal stress caused by the inflammation induced hyperalgesia can also induce augmented brain tribulin activity. The findings, thus, support the hypothesis that tribulin may function as an endogenous endocoid marker of stress.

摘要

在角叉菜胶诱导的大鼠急性爪部炎症过程中，研究了大鼠脑内源性单胺氧化酶（MAO）抑制剂（刺蒺藜素）的活性。大鼠脑内刺蒺藜素活性的增加与炎症的时间进程强度密切平行。该研究表明，与外部诱导的应激一样，由炎症诱导的痛觉过敏引起的内源性应激也可诱导脑内刺蒺藜素活性增强。因此，这些发现支持了刺蒺藜素可能作为应激的内源性内分泌标志物发挥作用的假说。