Laboratory of Drug Analysis, Scientific Institute of Public Health, Rue Juliette Wytsmanstraat 14, 1050 Brussels, Belgium.
J Pharm Biomed Anal. 2010 Nov 2;53(3):445-53. doi: 10.1016/j.jpba.2010.05.012. Epub 2010 May 19.
During this study, Fourier transform infrared spectroscopy (FT-IR), near infrared spectroscopy (NIR) and Raman spectroscopy were applied to 55 samples of counterfeit and imitations of Viagra and 39 samples of counterfeit and imitations of Cialis. The aim of the study was to investigate which of these techniques and associations of them were the best for discriminating genuine from counterfeit and imitation samples. Only the regions between 1800-400 cm(-1) and 7000-4000 cm(-1) were used for FT-IR and NIR spectroscopy respectively. Partial least square analysis has been used to allow the detection of counterfeit and imitation tablets. It is shown that for the Viagra samples, the best results were provided by a combination of FT-IR and NIR spectroscopy. On the other hand, the best results for the Cialis samples were provided by the combination of NIR and Raman spectroscopy (1400-1190 cm(-1)). These techniques not only permitted a clear discrimination between genuine and counterfeit or imitation samples but also the distinction of clusters among illegal samples. This might be interesting for forensic investigations by authorities.
在这项研究中，傅里叶变换红外光谱（FT-IR）、近红外光谱（NIR）和拉曼光谱被应用于 55 个假冒和仿冒伟哥的样本和 39 个假冒和仿冒希爱力的样本。研究的目的是调查这些技术以及它们的组合中哪一种最适合区分真假和假冒样本。仅使用 FT-IR 和 NIR 光谱的 1800-400 cm(-1) 和 7000-4000 cm(-1) 之间的区域。偏最小二乘分析已被用于检测假冒和仿造片剂。结果表明，对于伟哥样本，FT-IR 和 NIR 光谱的组合提供了最佳结果。另一方面，对于希爱力样本，NIR 和拉曼光谱（1400-1190 cm(-1)）的组合提供了最佳结果。这些技术不仅可以清楚地区分真假和假冒或仿造样本，还可以区分非法样本之间的聚类。这可能对当局的法证调查很有兴趣。
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