苯并呋喃取代的脲衍生物作为新型的 P2Y(1) 受体拮抗剂。
Benzofuran-substituted urea derivatives as novel P2Y(1) receptor antagonists.
机构信息
Department of Chemistry, Infectious Diseases Centre for Excellence in Drug Discovery, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA.
出版信息
Bioorg Med Chem Lett. 2010 Jul 15;20(14):4104-7. doi: 10.1016/j.bmcl.2010.05.072. Epub 2010 Jun 9.
PMID:20542694
Abstract
Benzofuran-substituted urea analogs have been identified as novel P2Y(1) receptor antagonists. Structure-activity relationship studies around the urea and the benzofuran moieties resulted in compounds having improved potency. Several analogs were shown to inhibit ADP-mediated platelet activation.
摘要
苯并呋喃取代的脲类似物已被鉴定为新型 P2Y(1) 受体拮抗剂。围绕脲和苯并呋喃部分的结构-活性关系研究产生了具有改善效力的化合物。一些类似物被证明可抑制 ADP 介导的血小板活化。
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