Galligioni E, Quaia M, Spada A, Crivellari D, Favaro D, Sorio R, Talamini R, D'Incalci M, Allavena P, Damia G
Centro di Riferimento Oncologico, Aviano (PN), Italy.
Ann Oncol. 1991 Feb;2(2):145-50. doi: 10.1093/oxfordjournals.annonc.a057879.
Natural killer (NK) cell activity was measured in nine patients with different solid tumors treated with flavone acetic acid (FAA). In three of them, NK cell activity was significantly increased, in two instances even after repeated courses of treatment. A significant increase in lymphokine activated killer (LAK) cell activity was also observed in three of four patients after in vivo treatment with FAA and in vitro incubation of lymphocytes with recombinant Interleukin-2. We observed some inter-individual variability in drug clearance, but no apparent correlation between drug plasma levels (neither peak nor AUC values) and the effects on NK and LAK activity.
对9例接受黄酮醋酸（FAA）治疗的不同实体瘤患者的自然杀伤（NK）细胞活性进行了测定。其中3例患者的NK细胞活性显著增加，有2例在重复疗程治疗后仍出现这种情况。在4例患者中，有3例在经FAA体内治疗以及淋巴细胞与重组白细胞介素-2体外孵育后，淋巴因子激活的杀伤（LAK）细胞活性也显著增加。我们观察到药物清除存在个体间差异，但药物血浆水平（峰值和AUC值）与对NK和LAK活性的影响之间没有明显相关性。
