Titus-Ernstoff L, Ernstoff M S, Duray P H, Barnhill R L, Holubkov R, Kirkwood J M
Department of Epidemiology, Yale University School of Medicine, New Haven, CT 06510.
Epidemiology. 1991 May;2(3):210-4. doi: 10.1097/00001648-199105000-00009.
We studied 117 patients with nonfamilial melanoma to determine whether melanoma patients with dysplastic nevus syndrome might be distinguished, on the basis of solar exposure, from melanoma patients without dysplastic nevus syndrome. Study participants were interviewed and received a skin examination, which included a total count of nevi, a standardized assessment of clinically atypical nevi, and the excision of each patient's clinically most atypical nevus. Based on the histologic review of the clinically most atypical nevus, each patient was classified as to whether dysplastic nevus syndrome was present or absent. Childhood sunburn with blistering and childhood recreational sun exposure were found to be associated with dysplastic nevus syndrome. The results suggest that childhood sun exposure increases risk of melanoma by initiating the melanoma precursor syndrome.
我们研究了117例非家族性黑色素瘤患者，以确定发育异常痣综合征的黑色素瘤患者是否可以根据日晒情况与无发育异常痣综合征的黑色素瘤患者区分开来。研究参与者接受了访谈并接受了皮肤检查，其中包括痣的总数、临床非典型痣的标准化评估，以及切除每位患者临床上最不典型的痣。根据临床上最不典型痣的组织学检查结果，每位患者被分类为是否存在发育异常痣综合征。发现儿童期水泡性晒伤和儿童期娱乐性日晒与发育异常痣综合征有关。结果表明，儿童期日晒通过引发黑色素瘤前驱综合征增加了患黑色素瘤的风险。
