Department of General Surgery C, La Paz University Hospital, Paseo de la Castellana 261, 28046, Madrid, Spain.
Int J Colorectal Dis. 2010 Dec;25(12):1447-51. doi: 10.1007/s00384-010-0952-3. Epub 2010 Jun 11.
Use of biosutures in animal models of colonic anastomoses is associated with decreased adhesions without affecting anastomotic strength. This study aimed to evaluate the effect of biosutures on colonic anastomoses kept free of adhesions by peritoneal instillation of icodextrin 4%.
Three types of colonic anastomoses were compared: group 1, anastomoses without icodextrin 4% and control suture; group 2, anastomoses with icodextrin 4% (adhesion-free anastomoses) and control suture; and group 3, anastomoses with icodextrin 4% (adhesion-free anastomoses) and biosutures. Dehiscence, adhesion formation, and anastomotic strength were evaluated on day 4 after the operation.
When peritoneal icodextrin 4% was used in anastomoses with conventional sutures, a decrease in the adhesion index (P = 0.01) and a lower bursting pressure (P = 0.15) were observed. When adhesion-free anastomoses were compared, those performed with biosutures had a higher bursting pressure (P = 0.008) and a similar pattern of adhesion index (P = 0.48).
Biosutures improve the strength of adhesion-free colonic anastomoses.
在结直肠吻合动物模型中使用生物缝线可减少粘连，而不影响吻合强度。本研究旨在评估在腹腔内注入艾考糊精 4%的情况下，生物缝线对无粘连结直肠吻合的影响。
比较了三种结直肠吻合术：第 1 组，无艾考糊精 4%和对照缝线的吻合术；第 2 组，有艾考糊精 4%（无粘连吻合术）和对照缝线的吻合术；第 3 组，有艾考糊精 4%（无粘连吻合术）和生物缝线的吻合术。术后第 4 天评估吻合口裂开、粘连形成和吻合强度。
当在常规缝线的吻合术中使用腹腔内艾考糊精 4%时，粘连指数降低（P=0.01），破裂压降低（P=0.15）。当比较无粘连吻合术时，使用生物缝线的吻合术具有更高的破裂压（P=0.008）和相似的粘连指数模式（P=0.48）。
生物缝线可提高无粘连结直肠吻合的强度。
