预测 HIV-1 不一致夫妇的妊娠情况。
Predicting pregnancy in HIV-1-discordant couples.
机构信息
Department of Epidemiology, University of Washington, Seattle, WA 98104-2499, USA.
出版信息
AIDS Behav. 2010 Oct;14(5):1066-71. doi: 10.1007/s10461-010-9716-x.
Abstract
This study examines the incidence and predictors of pregnancy in HIV-1-discordant couples from Nairobi, Kenya. Women from 454 discordant couples were followed for up to 2 years. One-year cumulative incidence of pregnancy was 9.7%. Pregnancy rates did not differ significantly between HIV-1-infected and uninfected women (HR = 1.46). The majority of pregnancies occurred among women < 30 years old reporting a desire for future children (1-year incidence 22.2%). Pregnancy rates may be high among discordant couples, indicating desire for children may override concerns of HIV-1 transmission and increase unprotected sex, and highlighting the need to make conception safer.
摘要
本研究考察了肯尼亚内罗毕的 HIV-1 不一致夫妇的妊娠发生率和预测因素。对 454 对不一致的夫妇进行了长达 2 年的随访。1 年累积妊娠发生率为 9.7%。HIV-1 感染和未感染妇女的妊娠率无显著差异（HR=1.46）。大多数妊娠发生在报告未来有生育愿望的年龄<30 岁的妇女中（1 年发生率为 22.2%）。不一致的夫妇中妊娠率可能较高，这表明对孩子的渴望可能超过对 HIV-1 传播的担忧，增加了无保护性行为的风险，突出了使受孕更安全的必要性。
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