Daniel D G, Kim E, Kostianovsky D, Goldberg T E, Casanova M F, Pickar D, Kleinman J E, Weinberger D R
Clinical Brain Disorders Branch, NIMH Neurosciences Center at Saint Elizabeths, Washington, DC 20032.
Biol Psychiatry. 1991 Apr 15;29(8):745-56. doi: 10.1016/0006-3223(91)90194-q.
Although previous studies have reported differences in computed tomography (CT) scan attenuation values between patients with schizophrenia and controls, interpretation of these findings has been hindered by methodological shortcomings such as the failure to control for head size, scanner calibration differences, and other confounding variables. In the present study of CT attenuation values in multiple brain regions in 20 patients with chronic schizophrenia and an equal number of age- and sex-matched normal subjects we controlled for head size and normalized the attenuation values for each scan to an internal standard. No significant differences emerged between the patients with schizophrenia and the controls. However, in the controls only, the mean density of white matter in the left frontal area was significantly higher (t = -2.83, p = 0.01) than that in the right. The results, although possibly suggestive of deviant lateralization in schizophrenia, raise questions about the sensitivity and validity of regional CT attenuation values in detecting subtle anatomic abnormalities in patients with this illness.
尽管先前的研究报告了精神分裂症患者与对照组在计算机断层扫描（CT）扫描衰减值上存在差异，但这些研究结果的解释受到了方法学缺陷的阻碍，如未能控制头部大小、扫描仪校准差异以及其他混杂变量。在本研究中，对20名慢性精神分裂症患者以及同等数量年龄和性别匹配的正常受试者的多个脑区CT衰减值进行了研究，我们控制了头部大小，并将每次扫描的衰减值归一化为内部标准。精神分裂症患者与对照组之间未出现显著差异。然而，仅在对照组中，左侧额叶白质的平均密度显著高于右侧（t = -2.83，p = 0.01）。这些结果虽然可能暗示精神分裂症存在异常的偏侧化，但也引发了关于区域CT衰减值在检测该疾病患者细微解剖异常方面的敏感性和有效性的问题。
