Kopylov Iu N, Golubeva L Iu
Biull Eksp Biol Med. 1991 Jan;111(1):22-5.
The effect of preliminary adaptation to intermittent (40 days, 4 hrs daily at 4000 m "altitude") on the resistance of myocardial energy metabolism and contractile function to acute anoxia and subsequent reoxygenation was studied. It was found that adaptation to hypoxia significantly accelerated the restoration of creatine phosphate, ATP and creatine phosphokinase activity in myocardium in reoxygenation following acute anoxia. On the whole, this effect reduces the competition of H+ with Ca2+ in myofibrils to improve the energy supply and to accelerate the restoration of myocardial contractile function in reoxygenation.
研究了预先适应间歇性（40天，每天4小时处于4000米“海拔”）对心肌能量代谢和收缩功能抵抗急性缺氧及随后复氧的影响。结果发现，对缺氧的适应显著加速了急性缺氧后复氧过程中心肌中磷酸肌酸、三磷酸腺苷（ATP）和肌酸磷酸激酶活性的恢复。总体而言，这种作用减少了氢离子与钙离子在肌原纤维中的竞争，以改善能量供应并加速复氧过程中心肌收缩功能的恢复。
