Shandra A A, Sudakov K V, Kryzhanovskiĭ G N
Biull Eksp Biol Med. 1991 Jan;111(1):49-52.
The antiepileptic action of neurotropin (Nippon Zoki Pharmaceutied Co. Ltd., Japan) was investigated in acute experiments on rats, mice and cats. The increasing of latent period of the first seizures which were picrotoxin-induced and enhancing of this type of seizures were observed correspondently in 1-24 hours and 8-9 days after intraventricular neurotropin injection. Intraperitoneal neurotropin injection (0.2-0.5 ml) to mice caused dosage-dependent antiseizure action on the model of generalized picrotoxin-induced seizures. +Anticonvulsant++ effect of neurotropin was observed during five days. The intraventricular neurotropin injection to cats led to strychnine (0.1%) induced cortical foci suppression.
在大鼠、小鼠和猫身上进行的急性实验中，研究了神经妥乐平（日本日本脏器制药株式会社）的抗癫痫作用。在脑室内注射神经妥乐平后的1 - 24小时和8 - 9天，分别观察到印防己毒素诱发的首次癫痫发作潜伏期延长以及此类癫痫发作增强。给小鼠腹腔注射神经妥乐平（0.2 - 0.5毫升）对印防己毒素诱发的全身性癫痫发作模型产生剂量依赖性的抗癫痫作用。神经妥乐平的抗惊厥作用持续了五天。给猫脑室内注射神经妥乐平可导致士的宁（0.1%）诱发的皮质病灶受到抑制。
