A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 119991 Moscow, Russian Federation.
Chemistry. 2010 Jul 26;16(28):8466-70. doi: 10.1002/chem.201000520.
The interaction of Ru(eta(6)-C(10)H(8))(Cp) (Cp=C(5)H(5)) with aromatic amino acids (L-phenylalanine, L-tyrosine, L-tryptophane, D-phenylglycine, and L-threo-3-phenylserine) under visible-light irradiation gives the corresponding Ru(eta(6)-amino acid)(Cp) complexes in near-quantitative yield. The reaction proceeds in air at room temperature in water and tolerates the presence of non-aromatic amino acids (except those which are sulfur containing), monosaccharides, and nucleotides. The complex Ru(eta(6)-C(10)H(8))(Cp) was also used for selective labeling of Tyr and Phe residues of small peptides, namely, angiotensin I and II derivatives.
[Ru(η6-C10H8)(Cp)]+（Cp=C5H5）与芳香族氨基酸（L-苯丙氨酸、L-酪氨酸、L-色氨酸、D-苯甘氨酸和 L-苏式-3-苯丝氨酸）在可见光照射下相互作用，以近乎定量的产率得到相应的[Ru(η6-氨基酸)(Cp)]+配合物。该反应在空气、室温、水中进行，并能耐受非芳香族氨基酸（含硫氨基酸除外）、单糖和核苷酸的存在。该配合物[Ru(η6-C10H8)(Cp)]+还用于选择性标记小肽（如血管紧张素 I 和 II 衍生物）中的 Tyr 和 Phe 残基。
