Simple synthesis of ruthenium pi complexes of aromatic amino acids and small peptides.

The interaction of Ru(eta(6)-C(10)H(8))(Cp) (Cp=C(5)H(5)) with aromatic amino acids (L-phenylalanine, L-tyrosine, L-tryptophane, D-phenylglycine, and L-threo-3-phenylserine) under visible-light irradiation gives the corresponding Ru(eta(6)-amino acid)(Cp) complexes in near-quantitative yield. The reaction proceeds in air at room temperature in water and tolerates the presence of non-aromatic amino acids (except those which are sulfur containing), monosaccharides, and nucleotides. The complex Ru(eta(6)-C(10)H(8))(Cp) was also used for selective labeling of Tyr and Phe residues of small peptides, namely, angiotensin I and II derivatives.