Nikitina A A, Solov'eva N A
Biull Eksp Biol Med. 1991 Jan;111(1):83-7.
The chronic ethanol effect on the cholinergic structures of frog's tongue epithelium was studied by means of histochemical method. It was found that the administration of ethanol daily for 14 days resulted in a decrease of reactive reorganization processes of the nerve fibers and nervous band perineurium, arising under stimulation of the tongue by taste solutions. This process was partly restored in a month, in spite of the continuing ethanol administration. The decrease of acetylcholinesterase activity and the appearance of dystrophic and destructive changes both in the nerve fibers and in neurons was observed in the animals subjected to lasting ethanol effect for 60-90 days. Revealed in the course of alcoholization morpho-functional changes of cholinergic tongue structures can be in the basis of the disturbance of the taste.
采用组织化学方法研究了慢性乙醇对蛙舌上皮胆碱能结构的影响。发现连续14天每日给予乙醇会导致在味觉溶液刺激舌时神经纤维和神经束膜神经带的反应性重组过程减弱。尽管继续给予乙醇，这一过程在一个月内部分恢复。在持续接受乙醇作用60 - 90天的动物中，观察到乙酰胆碱酯酶活性降低以及神经纤维和神经元中出现营养不良性和破坏性变化。在乙醇化过程中揭示的胆碱能舌结构的形态功能变化可能是味觉障碍的基础。
