College of Chemistry & Materials Engineering, Wenzhou University, Wenzhou 325035, People's Republic of China.
Org Lett. 2010 Jul 16;12(14):3238-41. doi: 10.1021/ol1011899.
(1)H NMR, in situ, determines the enantiomeric excess of reduced chiral alcohols or amines without adding any auxiliary and workup. The percent ee data determined by this method agree well with those given by HPLC. This approach may be potentially applicable to many asymmetric reductions.
(1) 1 H NMR 无需添加任何辅助试剂和进行后处理即可原位确定还原手性醇或胺的对映体过量值。该方法确定的百分ee 值与 HPLC 给出的值吻合良好。该方法可能潜在适用于许多不对称还原反应。
