Lange Rael T, Iverson Grant L, Brubacher Jeffrey R, Franzen Michael D
University of British Columbia, Vancouver, BC, Canada.
Brain Inj. 2010;24(7-8):919-27. doi: 10.3109/02699052.2010.489794.
It is a common clinical perception that alcohol intoxication systematically lowers Glasgow Coma Scale (GCS) scores when evaluating traumatic brain injury (TBI). However, the research findings in this area do not uniformly support this notion. The purpose of this study is to examine the effects of blood alcohol level (BAL) on GCS scores following TBI.
Participants were 475 patients (64% male) who presented to a Level 1 trauma centre following a TBI. Patients were selected if they were injured in a motor vehicle accident and had an available day-of-injury GCS, BAL and Computed Tomography (CT) brain scan.
Overall, acute alcohol intoxication did not significantly affect GCS scores, even in patients with BALs of 200 mg dl(-1) or higher. When controlling for the effects of injury severity, acute alcohol intoxication affected GCS scores only in those patients with BALs greater than 200 mg dl(-1) who also had intracranial abnormalities detected on CT scan.
These findings suggest that GCS scores can be interpreted at face value in the vast majority of patients who are intoxicated. However, GCS scores will likely over-estimate the severity of brain injury in patients with abnormal head CT scans and BALs greater than 200 mg dl(-1).
在评估创伤性脑损伤(TBI)时,临床普遍认为酒精中毒会系统性地降低格拉斯哥昏迷量表(GCS)评分。然而,该领域的研究结果并不一致支持这一观点。本研究的目的是探讨血酒精浓度(BAL)对TBI后GCS评分的影响。
研究对象为475例TBI后送至一级创伤中心的患者(64%为男性)。入选患者为在机动车事故中受伤且有受伤当日GCS评分、BAL及脑部计算机断层扫描(CT)结果的患者。
总体而言,急性酒精中毒并未显著影响GCS评分,即使是BAL达到或高于200 mg dl⁻¹的患者。在控制损伤严重程度的影响后,急性酒精中毒仅对那些BAL大于200 mg dl⁻¹且CT扫描发现颅内异常的患者的GCS评分有影响。
这些结果表明,在绝大多数酒精中毒患者中,GCS评分可按其表面数值进行解读。然而,对于头部CT扫描异常且BAL大于200 mg dl⁻¹的患者,GCS评分可能会高估脑损伤的严重程度。