Hannon Tamara S, Lee Sojung, Chakravorty Sangeeta, Lin Yan, Arslanian Silva A
Division of Weight Management and Wellness, Department of Pediatrics, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.
Int J Pediatr Obes. 2011 Apr;6(2):157-60. doi: 10.3109/17477166.2010.482156. Epub 2010 Jun 14.
Sleep-disordered breathing is associated with obesity, insulin resistance, and the metabolic syndrome in adults. Similar data in children is limited and conflicting. This pilot study examined the relationships between sleep-disordered breathing, visceral adiposity, and cardiometabolic risk factors in obese adolescents. Twenty obese (body mass index ≥ 95(th) percentile), otherwise healthy adolescents (age 14.9 ± 2 years) underwent polysomnogram studies, fasting lipid profile and oral glucose tolerance tests, and measures of body composition (dual-energy X-ray absorptiometry) and visceral adiposity (abdominal computed tomography). The severity of sleep-disordered breathing (as measured by apnea-hypopnea index) was positively associated with visceral adipose tissue (r = 0.73, p < 0.001) but not with other measures of body composition. After controlling for body mass index, the severity of sleep-disordered breathing was positively associated with markers of insulin resistance (homeostasis model assessment and fasting insulin). Further study to allow for critical assessment of the relationships between sleep-disordered breathing and cardiometabolic risk factors in obese youth remains necessary.
睡眠呼吸障碍与成人的肥胖、胰岛素抵抗及代谢综合征相关。儿童中的类似数据有限且相互矛盾。这项初步研究探讨了肥胖青少年睡眠呼吸障碍、内脏脂肪过多与心脏代谢危险因素之间的关系。20名肥胖（体重指数≥第95百分位数）但其他方面健康的青少年（年龄14.9±2岁）接受了多导睡眠图检查、空腹血脂谱和口服葡萄糖耐量试验，以及身体成分测量（双能X线吸收法）和内脏脂肪测量（腹部计算机断层扫描）。睡眠呼吸障碍的严重程度（通过呼吸暂停低通气指数衡量）与内脏脂肪组织呈正相关（r = 0.73，p < 0.001），但与其他身体成分测量指标无关。在控制体重指数后，睡眠呼吸障碍的严重程度与胰岛素抵抗标志物（稳态模型评估和空腹胰岛素）呈正相关。仍有必要进行进一步研究，以便对肥胖青少年睡眠呼吸障碍与心脏代谢危险因素之间的关系进行批判性评估。
