Department of Biomedical Engineering, Brain Korea 21 Project for Biomedical Science, College of Medicine, Korea University, Seoul, Korea.
Artif Organs. 2010 Jul;34(7):554-60. doi: 10.1111/j.1525-1594.2010.01039.x. Epub 2010 Jun 10.
Since the occlusive-type pulsatile extracorporeal blood pump (Twin-Pulse Life Support System; Seoul National University, Seoul, Korea) received the CE mark of the European Directives and Korea Food and Drug Administration approval (2004) for short-term applications as an extracorporeal life support system, the pump system has been tested for hemolysis. This pump system was recently upgraded with an ameliorated pusher plate to reduce hemolysis. In this study, numerical analysis and in vitro tests were performed to determine the optimal conditions for increasing the durability of the blood sac and pump output. During the simulation, the minimum sliding interface force (SIF) for the angle of the pusher plate movement (PPM) was calculated (40-70 degrees ). In the in vitro durability test, the angle of the PPM was increased gradually from 40 to 70 degrees in 10 degrees increments, and the mean time to failure (MTTF) of the blood sac was calculated. Fifteen tests were conducted for each case: 40, 50, 60, and 70 degrees (n = 15 each). The MTTF of the blood sac was defined as the time when a crack of the blood sac occurred. The longer lifetime of the blood sac at 60 degrees of the PPM (297.0 h) than that at 50 degrees (197.6 h) was attributed to the lower SIF value (-0.13, normalized value) at 60 degrees of the PPM.
由于闭塞型脉动式体外血液泵（Twin-Pulse Life Support System；韩国首尔国立大学）获得了欧洲指令和韩国食品药品管理局的 CE 标志认证（2004 年），可短期应用于体外生命支持系统，该泵系统已进行了溶血测试。该泵系统最近进行了升级，采用改良的推压器来减少溶血。本研究通过数值分析和体外测试，确定了增加血袋和泵输出耐久性的最佳条件。在模拟过程中，计算了推压器运动角度（PPM）的最小滑动界面力（SIF）（40-70 度）。在体外耐久性测试中，将 PPM 的角度从 40 度逐渐增加到 70 度，每 10 度增加一次，计算血袋的平均失效时间（MTTF）。每个角度进行了 15 次测试：40、50、60 和 70 度（n = 15）。血袋的 MTTF 定义为血袋出现裂缝的时间。PPM 角度为 60 度时的血袋寿命（297.0 h）长于 PPM 角度为 50 度时的寿命（197.6 h），这归因于 PPM 角度为 60 度时较低的 SIF 值（-0.13，归一化值）。
