McLaughlin-Rotman Centre for Global Health, University Health Network-Toronto General Hospital, University of Toronto, Toronto, ON, Canada.
Cell Microbiol. 2010 Aug;12(8):1036-45. doi: 10.1111/j.1462-5822.2010.01492.x. Epub 2010 Jun 11.
Severe malaria remains a major cause of global mortality. The innate immune response to infection is a key determinant of malaria severity and outcome. The complement system plays a key role in initiating and augmenting innate immune responses, including inflammation, endothelial activation, opsonization and coagulation, processes which have been implicated in malaria pathogenesis. In this review, we discuss the evidence supporting a role for excessive complement activation in the pathogenesis of severe malaria.
严重疟疾仍然是全球死亡的主要原因。感染的先天免疫反应是疟疾严重程度和结果的关键决定因素。补体系统在启动和增强先天免疫反应中起着关键作用，包括炎症、内皮细胞激活、调理作用和凝血，这些过程与疟疾发病机制有关。在这篇综述中，我们讨论了支持补体过度激活在严重疟疾发病机制中的作用的证据。
