Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Clin Exp Dermatol. 2011 Mar;36(2):169-73. doi: 10.1111/j.1365-2230.2010.03874.x.
There is a dearth of studies comparing the efficacy of psoralen ultraviolet A (PUVA) and narrowband (NB)-UVB in psoriasis in South Asian patients. Patients having plaque psoriasis with > 20% body surface area involvement were randomly assigned to one of two groups (group A: NB-UVB, group B: PUVA). The response to treatment was assessed by the Psoriasis Area and Severity Index (PASI) at baseline and every 2 weeks thereafter. The maximum possible treatment duration was 16 weeks. In total, 43 patients (21 NB-UVB, 22 PUVA) completed the study. Marked improvement was seen in 80.9% of the patients in group A and 81.8% in group B (NS: P > 0.05). The mean ± SD time taken to achieve marked improvement was 9.9 ± 3.3 and 9.9 ± 3.5 weeks, respectively. In total, 29 patients were available for the analysis of the remission data at 6 months after treatment completion; 26.7% of the patients in group A and 42.8% in group B were in remission (NS: P > 0.05). Both methods seem to be equally effective in achieving clearance and maintaining remission of severe chronic plaque psoriasis in patients with Fitzpatrick skin type 4 and 5.
在南亚患者中，比较补骨脂素加紫外线 A（PUVA）和窄谱（NB）-UVB 治疗银屑病疗效的研究很少。将患有> 20%体表面积受累斑块状银屑病的患者随机分配到两组之一（A 组：NB-UVB，B 组：PUVA）。在基线和此后每 2 周通过银屑病面积和严重程度指数（PASI）评估治疗反应。最大可能治疗持续时间为 16 周。共有 43 名患者（21 名 NB-UVB，22 名 PUVA）完成了研究。A 组 80.9%和 B 组 81.8%的患者明显改善（NS：P > 0.05）。达到明显改善的平均（±SD）时间分别为 9.9 ± 3.3 和 9.9 ± 3.5 周。共有 29 名患者可用于治疗完成后 6 个月的缓解数据分析；A 组 26.7%和 B 组 42.8%的患者缓解（NS：P > 0.05）。在 Fitzpatrick 皮肤类型 4 和 5 的患者中，两种方法似乎都同样有效，可以清除和维持严重慢性斑块状银屑病的缓解。
