经尿道整块切除（TURBO）是膀胱肿瘤病理分期的准确工具。

Transurethral resection in one piece (TURBO) is an accurate tool for pathological staging of bladder tumor.

机构信息

Department of Urology, Hiroshima General Hospital of West Japan Railway Company, Hiroshima, Japan.

出版信息

Int J Urol. 2010 Aug;17(8):708-14. doi: 10.1111/j.1442-2042.2010.02571.x. Epub 2010 Jun 9.

DOI:10.1111/j.1442-2042.2010.02571.x

PMID:20546051

Abstract

OBJECTIVES

To demonstrate the usefulness of transurethral resection in one piece (TURBO) as an accurate pathological staging tool for bladder tumor.

METHODS

Ninety-seven patients with newly diagnosed bladder cancer underwent TURBO that was performed either in an en bloc or in a divisional manner. The histological quality of the resection specimens was evaluated and the pathological stage was assigned on the basis of the depth of invasion, which was histologically determined.

RESULTS

Specimens obtained by TURBO were well oriented and their 3-D architecture was maintained. This allowed a histological assessment of the entire specimen. Portions of muscularis propria were identified beneath the tumor base in the specimens of 80 (82%) patients. In only seven (7%) patients, the tumors had a deep resection margin positive for carcinoma and were ambiguously staged as "pT1 or higher" or "pT2 or higher". Thus, definite pathological staging of TURBO specimens was possible in 90 (93%) patients (pTa, 30; pT1, 58; pT2, 2).

CONCLUSIONS

An accurate pathological stage can be assigned to the TURBO specimen in most bladder cancer patients.

摘要

目的

展示经尿道整块切除术（TURBO）作为膀胱肿瘤准确病理分期工具的实用性。

方法

97 例新诊断为膀胱癌的患者接受了 TURBO 治疗，该治疗采用整块或分片方式进行。评估切除标本的组织学质量，并根据组织学确定的浸润深度确定病理分期。

结果

TURBO 获得的标本定向良好，其 3D 结构得以维持。这允许对整个标本进行组织学评估。在 80 例（82%）患者的标本中，在肿瘤基底下方可以识别出部分固有肌层。仅在 7 例（7%）患者中，肿瘤的深部切缘有癌阳性，病理分期为“pT1 或更高”或“pT2 或更高”存在歧义。因此，90 例（93%）患者的 TURBO 标本可以进行明确的病理分期（pTa，30 例；pT1，58 例；pT2，2 例）。