持续性瘙痒性丘疹和斑块：在成人发病型和青少年型斯蒂尔病的一部分患者中所见的特征性组织病理学表现。
Persistent pruritic papules and plaques: a characteristic histopathologic presentation seen in a subset of patients with adult-onset and juvenile Still's disease.
作者信息
Fortna Ryan R, Gudjonsson Johann E, Seidel Gregory, Dicostanzo Damian, Jacobson Mark, Kopelman Margaret, Patel Rajiv M
机构信息
Department of Pathology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA.
出版信息
J Cutan Pathol. 2010 Sep;37(9):932-7. doi: 10.1111/j.1600-0560.2010.01570.x. Epub 2010 Jun 10.
BACKGROUND
'Persistent pruritic papules and plaques' of Still's disease represents a recently described eruption seen in a subset of patients. Most cases reported in the literature to date have been associated with adult-onset Still's disease.
METHODS
We present the clinical and histopathologic examinations of three female patients ranging in age from 15 to 54 years.
RESULTS
Our three patients each presented with clinical findings consistent with Still's disease. The youngest patient suffered from the juvenile form of Still's disease (systemic-onset juvenile rheumatoid arthritis). Each patient had a persistent, pruritic eruption with histopathologic findings of dyskeratosis confined to the upper layers of the epidermis as well as a sparse superficial dermal infiltrate containing scattered neutrophils.
CONCLUSIONS
These cases confirm the characteristic clinical and histopathologic findings of 'persistent papules and plaques of Still's disease' and show the potential for this eruption in both the adult and juvenile age groups.
背景
斯蒂尔病的“持续性瘙痒性丘疹和斑块”是最近在一部分患者中发现的一种皮疹。迄今为止，文献报道的大多数病例与成人斯蒂尔病有关。
方法
我们对3名年龄在15至54岁之间的女性患者进行了临床和组织病理学检查。
结果
我们的3名患者均表现出与斯蒂尔病相符的临床症状。最年轻的患者患有青少年型斯蒂尔病（全身型幼年特发性关节炎）。每名患者都有持续性瘙痒性皮疹，组织病理学表现为角化不良局限于表皮上层，以及稀疏的浅表真皮浸润，其中含有散在的中性粒细胞。
结论
这些病例证实了“斯蒂尔病持续性丘疹和斑块”的特征性临床和组织病理学表现，并显示了这种皮疹在成人和青少年年龄组中出现的可能性。
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