Simmet T, Tippler B
Department of Pharmacology and Toxicology, Ruhr-University Bochum, Germany.
Brain Res. 1991 Feb 1;540(1-2):283-6. doi: 10.1016/0006-8993(91)90519-2.
In gerbils pentylenetetrazole- or handling-induced seizures were accompanied by cerebral formation of small amounts of cysteinyl-leukotrienes (LT) but large amounts of prostaglandin (PG) F2 alpha. By contrast, in rats injected with pentylenetetrazole or bicuculline very large amounts of PGF2 alpha but no cysteinyl-LT could be detected in the brain tissues. The data indicate that at least in rats the extensive neuronal activity during tonic-clonic convulsions is not necessarily sufficient for the activation of the 5-lipoxygenase pathway. Apparently important species differences do exist.
