肉毒杆菌毒素 A 与甾体类药物和局部麻醉剂混合治疗骶髂关节疼痛的临床疗效比较。
Clinical effectiveness of botulinum toxin A compared to a mixture of steroid and local anesthetics as a treatment for sacroiliac joint pain.
机构信息
Department of Physical Medicine and Rehabilitation, Wooridul Spine Hospital, Seoul, Korea.
出版信息
Pain Med. 2010 May;11(5):692-700. doi: 10.1111/j.1526-4637.2010.00838.x.
OBJECTIVE
The sacroiliac joint (SIJ) is one of the sources of low back pain and referred pain to the lower limb. Steroid injections have been used to treat SIJ pain, but this frequently necessitates repeated injections. Botulinum toxin (BT) type A has been shown to provide significant reduction of joint pain, and functional improvements. This study investigated the efficacy of BT for reducing SIJ pain and maintaining a clinical effect, compared with steroid injections.
DESIGN
Prospective case control study.
SETTING
Spine hospital.
PATIENTS
Patients who were diagnosed with SIJ syndrome based on physical examination and diagnostic SIJ injection were selected.
INTERVENTIONS
Either Dysport (BT group) or a mixture of triamcinolone and lidocaine (triamcinolone and local anesthetics [TA] group) was injected into the posterior sacroiliac ligaments under C-arm fluoroscopy.
OUTCOME MEASURES
Numeric Rating Scale (NRS) and Oswestry Disability Index (ODI) were used for evaluation at pretreatment, 1 month, 2 months, and 3 months after treatment.
RESULTS
At 1 month, the BT and TA group showed no significant differences in NRS or ODI. However, at 2 and 3 months, the BT group had significantly lower scores in NRS and ODI than did the TA group.
CONCLUSION
BT shows clinical usefulness in pain reduction and for functional improvement in patients with SIJ pain. This effect was maintained for 3 months following the injection, by which time the effects of TA had diminished.
目的
骶髂关节(SIJ)是腰痛和下肢牵涉痛的来源之一。甾体注射已被用于治疗 SIJ 疼痛,但这通常需要重复注射。A型肉毒毒素(BT)已被证明能显著减轻关节疼痛和改善功能。本研究比较了 BT 与甾体注射治疗 SIJ 疼痛的疗效,以评估 BT 维持临床疗效的能力。
设计
前瞻性病例对照研究。
地点
脊柱医院。
患者
根据体格检查和诊断性 SIJ 注射诊断为 SIJ 综合征的患者入选。
干预
在 C 臂透视引导下,在后骶髂韧带内注射 Dysport(BT 组)或曲安奈德和利多卡因混合物(曲安奈德和局部麻醉剂 [TA] 组)。
评价指标
治疗前、治疗后 1 个月、2 个月和 3 个月时采用数字评分量表(NRS)和 Oswestry 残疾指数(ODI)进行评估。
结果
在 1 个月时,BT 组和 TA 组的 NRS 和 ODI 无显著差异。然而,在 2 个月和 3 个月时,BT 组的 NRS 和 ODI 评分明显低于 TA 组。
结论
BT 可显著减轻 SIJ 疼痛患者的疼痛,并改善其功能。这种效果在注射后 3 个月内持续存在,此时 TA 的效果已经减弱。