Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.
J Neuroimmunol. 2010 Aug 25;225(1-2):171-4. doi: 10.1016/j.jneuroim.2010.04.017. Epub 2010 May 23.
The up-regulation of MHC in muscles is thought to be associated with inflammatory myopathies. The expression of MHC class I and class II was examined in muscles of myasthenia gravis (MG). MG muscle specimens from all 5 patients with thymoma and 2 of 5 without thymoma showed MHC class I up-regulation and 3 of 5 with thymoma showed MHC class II. The up-regulation of MHC in MG muscles is thus considered to be a common phenomenon. MG muscles expressed not only MHC class I but also class II, and these muscles could thus act as immunoregulating cells in MG.
肌肉中 MHC 的上调被认为与炎症性肌病有关。在重症肌无力 (MG) 的肌肉中检查了 MHC Ⅰ类和Ⅱ类的表达。5 例胸腺瘤患者和 5 例无胸腺瘤患者中的 2 例均显示 MHC Ⅰ类上调，5 例胸腺瘤中有 3 例显示 MHC Ⅱ类。因此，MG 肌肉中 MHC 的上调被认为是一种常见现象。MG 肌肉不仅表达 MHC Ⅰ类，还表达 MHC Ⅱ类，因此这些肌肉可以在 MG 中充当免疫调节细胞。
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