载喜树碱的 N-三甲基壳聚糖纳米粒在肝癌临床前小鼠模型中的体内抗肿瘤和抗转移活性。

In vivo antitumor and antimetastatic activities of camptothecin encapsulated with N-trimethyl chitosan in a preclinical mouse model of liver cancer.

机构信息

Department of Gynecology and Obstetrics, West China Second Hospital, Sichuan University, Chengdu, People's Republic of China.

出版信息

Cancer Lett. 2010 Nov 1;297(1):56-64. doi: 10.1016/j.canlet.2010.04.024. Epub 2010 May 23.

DOI:10.1016/j.canlet.2010.04.024

PMID:20546992

Abstract

Application of camptothecin (CPT) is hampered due to its extreme water insolubility and unpredictable side effects. Therefore, it is essential to establish an efficient and safe protocol for the administration of camptothecin against tumor growth and metastasis. Here, we encapsulated camptothecin with N-trimethyl chitosan (CPT-TMC) and tested it on BALB/c mice subcutaneously injected with murine hepatocellular carcinoma cells at the hindlimb feet pad. CPT-TMC effectively inhibited tumor growth and lymphatic metastasis, prolonged survival time, yet without apparent toxic effects. Thus, CPT-TMC may provide a novel and effective therapeutic strategy against human advanced hepatic cancer without conspicuous systemic toxic effects.

摘要

喜树碱（CPT）由于其极难溶于水和不可预测的副作用，其应用受到了阻碍。因此，建立一种高效、安全的喜树碱给药方案来抑制肿瘤生长和转移至关重要。在这里，我们用 N-三甲基壳聚糖（CPT-TMC）包裹喜树碱，并在 BALB/c 小鼠后腿脚掌皮下注射小鼠肝癌细胞后对其进行了测试。CPT-TMC 能有效抑制肿瘤生长和淋巴转移，延长生存期，且无明显的毒副作用。因此，CPT-TMC 可能为治疗人类晚期肝癌提供了一种新颖而有效的治疗策略，且无明显的全身毒性作用。