Dubost J, Roche C, Kalfon F
Département d'Anesthésie-Réanimation, Centre hospitalier Lyon-Sud, Pierre-Bénite.
Cah Anesthesiol. 1991;39(1):9-12.
The aim of this study was to check local and general tolerance as well as anxiolytic and amnesic effects of midazolam intramuscular administration as a premedication in 4 to 10 years old children. A double blind, comparative study with a placebo was achieved, after drawing lots, in 40 children divided into two equal groups. Premedication consisted of either midazolam or injectable water administrated with a posology of 0.3 to 0.5 mg.kg-1 combined, in both cases, with atropine sulfate (0.015 mg.kg-1). Results confirmed good local and general tolerance. Also anterograde amnesia was found to be excellent: 17 children in the midazolam group did not remember a photograph shown after premedication, instead of only one in the placebo group. Anxiolytic effects, similar in both groups, cannot be considered owing to the too short interval of time from premedication to induction.
本研究的目的是检验咪达唑仑肌肉注射作为4至10岁儿童术前用药的局部和全身耐受性以及抗焦虑和遗忘作用。在40名儿童中通过抽签进行了一项双盲、安慰剂对照研究，将其分为两组，每组人数相等。术前用药包括咪达唑仑或注射用水，剂量为0.3至0.5 mg·kg-1，两种情况下均联合硫酸阿托品（0.015 mg·kg-1）。结果证实了良好的局部和全身耐受性。此外，还发现顺行性遗忘效果极佳：咪达唑仑组有17名儿童在术前用药后不记得看过的一张照片，而安慰剂组只有1名儿童不记得。由于从术前用药到诱导的时间间隔过短，两组相似的抗焦虑作用无法评估。
