Department of Microbiology, New York University School of Medicine, 550 First Avenue MSB 236, New York, NY 10016, USA.
Trends Biochem Sci. 2010 Jun;35(6):348-51. doi: 10.1016/j.tibs.2010.03.003. Epub 2010 May 23.
For some time, post-translational small protein modifications were found only in eukaryotes; much later, such modifications were identified in some species of bacteria. The recent discovery of ubiquitin-like proteins that form polymeric chains and covalently modify proteins in archaea finally closes the evolutionary gap among the domains of life.
一段时间以来,翻译后小蛋白修饰只在真核生物中被发现;直到后来,在一些细菌物种中也鉴定到了这种修饰。最近发现的泛素样蛋白可以形成聚合链,并在古菌中使蛋白质发生共价修饰,最终填补了生命领域之间的进化空白。