埃及冠状动脉疾病中的内皮型一氧化氮合酶和血管紧张素原基因多态性。
Endothelial nitric oxide synthase and angiotensinogen gene polymorphism in coronary artery diseases in Egypt.
机构信息
Department of Biochemistry, Faculty of Pharmacy, Cairo University, Egypt.
出版信息
Angiology. 2011 Feb;62(2):191-7. doi: 10.1177/0003319710373094. Epub 2010 Jun 13.
Genetic factors contribute to the pathogenesis of coronary artery disease (CAD). We studied 100 patients with CAD and 50 healthy individuals to assess the association of endothelial nitric oxide (eNOS) polymorphism (Glu298Asp) and angiotensinogen polymorphisms (M235T) and CAD in an Egyptian population. Serum nitric oxide (NO) and angiotensin I levels were also measured. The frequency of Glu298Asp and M235T polymorphisms were higher in the CAD group compared with controls. The mean level of NO was significantly lower (P < .05) while angiotensin I was significantly higher (P < .05) in patients CAD than in controls. The frequency of eNOS TT allele of M235T variant was significantly higher in patients with CAD (20% vs 6%). The frequency of angiotensinogen (AGT) TT and T allele in patients with CAD was significantly higher (P < .05) than in controls (22% vs 6%and 47% vs23%, respectively). Homozygosity for Glu298Asp and M235T polymorphisms may predispose to CAD.
遗传因素导致冠心病（CAD）的发病机制。我们研究了 100 例 CAD 患者和 50 例健康个体，以评估内皮型一氧化氮合酶（eNOS）多态性（Glu298Asp）和血管紧张素原多态性（M235T）与埃及人群中 CAD 的相关性。还测量了血清一氧化氮（NO）和血管紧张素 I 水平。与对照组相比，CAD 组的 Glu298Asp 和 M235T 多态性频率更高。CAD 患者的平均 NO 水平显著降低（P <.05），而血管紧张素 I 水平显著升高（P <.05）。与对照组相比，CAD 患者的 eNOS M235T 变体 TT 等位基因频率明显更高（20%对 6%）。与对照组相比，CAD 患者的血管紧张素原（AGT）TT 和 T 等位基因频率明显更高（P <.05）（分别为 22%对 6%和 47%对 23%）。Glu298Asp 和 M235T 多态性的纯合性可能导致 CAD 易感性。
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