鼻咽癌恶性上皮细胞中的EB病毒核抗原
Epstein-Barr virus-determined nuclear antigen in malignant epithelial cells of nasopharyngeal carcinoma.
作者信息
Suzuki T, Katano A, Oboshi S, Sairenji T, Hinuma Y
出版信息
Gan. 1978 Feb;69(1):133-8.
PMID:205477
Abstract
Tumor tissue from lymph node metastasis of nasopharyngeal carcinoma (NPC) was successfully heterotransplanted into an athymic nude mouse and the tumor grown in the nude mouse was identical in its morphology to that form the patient by optical and electron microscopy. Tumor cells at passage 2 were dispersed in vitro by enzymic digestion and smeared. Epstein-Barr virus-determined nuclear antigen (EBNA) was demonstrated in malignant epithelial cells of the smear.
摘要
成功地将鼻咽癌（NPC）淋巴结转移灶的肿瘤组织异种移植到无胸腺裸鼠体内，通过光学显微镜和电子显微镜观察发现，裸鼠体内生长的肿瘤在形态上与患者的肿瘤相同。第2代肿瘤细胞经酶消化后在体外分散并涂片。在涂片的恶性上皮细胞中检测到了EB病毒核抗原（EBNA）。
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