一种新型氨基酸衍生物N6,N9-双（丁氧羰基氨甲基）-L-瓜氨酸的抗肿瘤活性
Antitumor activity of a new amino acid derivative, N6,N9-bis-(butyloxycarbonylaminomethyl)-L-citrulline.
作者信息
Fujita H, Seto Y, Sakurai T, Ichimura H, Satoh H, Toyoshima S
出版信息
Gan. 1978 Feb;69(1):99-101.
PMID:205478
Abstract
Approximately 800 amino acid derivatives have been synthesized and screened in order to evaluate their antitumor activity against various transplantable rat ascites hepatomas. Among them, N6,N9-bis(butyloxycarbonylaminomethyl)-L-citrulline (A-924) was found to be highly effective against various rat ascites hepatomas. A-924, when given orally, exhibited prolongation of survival of rats implanted intravenously with ascites hepatoma cells such as AH-44, AH-66, AH-130, AH-66F, or AH-41C.
摘要
为了评估大约800种氨基酸衍生物对各种可移植大鼠腹水肝癌的抗肿瘤活性，已对其进行了合成和筛选。其中，N6,N9-双（丁氧羰基氨甲基）-L-瓜氨酸（A-924）被发现对各种大鼠腹水肝癌具有高效性。口服A-924可延长静脉注射腹水肝癌细胞（如AH-44、AH-66、AH-130、AH-66F或AH-41C）的大鼠的生存期。
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