• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Studies on cardiotonic agents. VI. Synthesis of novel 4,5-dihydro-3(2H)-pyridazinone derivatives carrying some benzoheterocycles at the 6-position.

作者信息

Nomoto Y, Takai H, Ohno T, Kubo K

机构信息

Pharmaceutical Research Laboratories, Fuji Kyowa Hakko Kogyo Co., Ltd., Shizuoka, Japan.

出版信息

Chem Pharm Bull (Tokyo). 1991 Feb;39(2):352-7. doi: 10.1248/cpb.39.352.

DOI:10.1248/cpb.39.352
PMID:2054859
Abstract

Several benzothiazolyl, imidazobenzothiazolyl, benzothienyl, benzothienopyrimidinyl and quinazolinyl 4,5-dihydro-3(2H)-pyridazinones were synthesized and examined for cardiotonic activity in anesthetized dogs after i.v. administration. Among them, 4-methylamino-7-(2,3,4,5-tetrahydro-5-methyl-3-oxo-6- pyridazinyl)quinazoline (36) showed potent and long-lasting inotropic activity (relative potency = 2.11, milrinone = 1). The activity of 36 was more potent than indolidan (2) (relative potency = 1.53) which is one of the most potent inotropic agents to date.

摘要

相似文献

1
Studies on cardiotonic agents. VI. Synthesis of novel 4,5-dihydro-3(2H)-pyridazinone derivatives carrying some benzoheterocycles at the 6-position.
Chem Pharm Bull (Tokyo). 1991 Feb;39(2):352-7. doi: 10.1248/cpb.39.352.
2
Cardiotonic agents. 2. Synthesis and structure-activity relationships of 4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones: a new class of positive inotropic agents.
J Med Chem. 1985 Oct;28(10):1405-13. doi: 10.1021/jm00148a006.
3
Dihydropyridazinone cardiotonics: the discovery and inotropic activity of 1,3-dihydro-3,3-dimethyl-5-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)-2H -indol-2- one.二氢哒嗪酮强心剂：1,3 - 二氢 - 3,3 - 二甲基 - 5 - (1,4,5,6 - 四氢 - 6 - 氧代 - 3 - 哒嗪基)-2H - 吲哚 - 2 - 酮的发现及正性肌力活性
J Med Chem. 1986 Oct;29(10):1832-40. doi: 10.1021/jm00160a006.
4
Cardiotonic agents. 9. Synthesis and biological evaluation of a series of (E)-4,5-dihydro-6-[2-[4-(1H-imidazol-1-yl)phenyl]ethenyl]-3 (2H)-pyridazinones: a novel class of compounds with positive inotropic, antithrombotic, and vasodilatory activities for the treatment of congestive heart failure.强心剂。9. 一系列(E)-4,5-二氢-6-[2-[4-(1H-咪唑-1-基)苯基]乙烯基]-3(2H)-哒嗪酮的合成与生物学评价：一类用于治疗充血性心力衰竭的具有正性肌力、抗血栓形成和血管舒张活性的新型化合物。
J Med Chem. 1989 Feb;32(2):342-50. doi: 10.1021/jm00122a011.
5
Design, synthesis and structure-activity relationship studies of 6-phenyl-4,5-dihydro-3(2H)-pyridazinone derivatives as cardiotonic agents.作为强心剂的6-苯基-4,5-二氢-3(2H)-哒嗪酮衍生物的设计、合成及构效关系研究
Arzneimittelforschung. 2008;58(11):569-73. doi: 10.1055/s-0031-1296558.
6
Cardiotonic agents. 4. Synthesis and biological evaluation of N-substituted 2,4,4a,5-tetrahydro-3H-indeno[1,2-c]pyridazin-3-ones: rigid structures derived from CI-930 and analogues.
J Med Chem. 1986 Nov;29(11):2142-8. doi: 10.1021/jm00161a003.
7
Cardiotonic agents. 3. Synthesis and biological activity of novel 6-(substituted 1H-imidazol-4(5)-yl)-3(2H)-pyridazinones.强心剂。3. 新型6-（取代的1H-咪唑-4（5）-基）-3（2H）-哒嗪酮的合成及生物活性
J Med Chem. 1986 Feb;29(2):261-7. doi: 10.1021/jm00152a015.
8
Imidazole-pyridine bioisosterism: comparison of the inotropic activities of pyridine- and imidazole-substituted 6-phenyldihydropyridazinone cardiotonics.
J Med Chem. 1988 Feb;31(2):461-5. doi: 10.1021/jm00397a033.
9
Cardiotonic agents. 6. Synthesis and inotropic activity of 2,4-dihydro-5-[4-(1H-imidazol-1-yl)phenyl]-3H-pyrazol-3-ones: ring-contracted analogues of imazodan (CI-914).
J Med Chem. 1987 Oct;30(10):1724-8. doi: 10.1021/jm00393a007.
10
Cardiovascular effects of NSP-804 and NSP-805, novel cardiotonic agents with vasodilator properties.具有血管舒张特性的新型强心剂NSP - 804和NSP - 805对心血管的影响。
J Cardiovasc Pharmacol. 1993 Jun;21(6):983-95. doi: 10.1097/00005344-199306000-00021.

引用本文的文献

1
Methylsulfonyl benzothiazole (MSBT): a selective protein thiol blocking reagent.甲基磺酰苯并噻唑（MSBT）：一种选择性蛋白质巯基阻断试剂。
Org Lett. 2012 Jul 6;14(13):3396-9. doi: 10.1021/ol301370s. Epub 2012 Jun 8.