海兔毒素C1-C15结构域的合成。
A synthesis of the C1-C15 domain of the halichondrins.
作者信息
Jackson Katrina L, Henderson James A, Morris Jonathan C, Motoyoshi Hajime, Phillips Andrew J
机构信息
Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309-0215, USA.
出版信息
Tetrahedron Lett. 2008 Apr 1;49(18):2939-2941. doi: 10.1016/j.tetlet.2008.03.018.
Abstract
A concise route to the C1-C15 domain of the halichondrins is described. The key reaction is the conversion of a furfuryl alcohol to a pyranone. The stereocenter of this pyranone serves as the starting point for the other 8 stereocenters.
摘要
本文描述了一种合成海兔毒素C1-C15结构域的简洁方法。关键反应是将糠醇转化为吡喃酮。该吡喃酮的立体中心是其他8个立体中心的起始点。
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